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Metabolic Bone Disease Review

Metabolic Bone Disease, also known as metabolic osteoporosis, is a relatively new field. This is because, although not a widely recognized medical disorder, it has been observed over the last few years that thousands of people all around the world suffer from a condition known as osteoporosis. Osteoporosis is a universal problem, but its symptoms are surprisingly common. The most familiar symptoms are broken bones, particularly those found in the neck, wrist, legs, shoulders, or upper back. Osteoporosis usually starts from a family history of fractures. It can then develop into a serious problem that causes pain, limitation of movement, loss of muscle strength, decreased vision, and decreased resistance to impact.

Metabolic Bone Disease Symptoms

Because the majority of the metabolic bone disease has no symptoms, this condition may result in death. In order to detect whether the body is subjected to abnormal metabolic bone disease, tests for the biochemical markers, alkaline phosphate, calcium, cystine, and total alkalinity should be carried out regularly. An abnormally low level of cystine or an abnormally high level of sulfur may result in a diagnosis of cystic fibrosis. A chronic abnormality in liver function may lead to liver failure, kidney stones, and a higher risk of developing kidney cancer.

Metabolic osteoporosis has a genetic component, so if one of the parents suffers from the condition, there is a good chance that a child may follow suit. Some other conditions that have a genetic component include cystic fibrosis, cystic nodular acne, and multiple sclerosis. The symptoms of metabolic bone disease include severe pain, weakness, fractures, decreased bone density, abnormal calcium levels, and loss of muscle strength. Blood tests can reveal the levels of calcium, pyridoxine, trans-sulfated polysaccharides (TSP), pyridoxine, insulin, total cholesterol, glycoside levels, and hemoglobin. Blood tests can also reveal the presence of vitamin D, uric acid, folate, homocysteine, glycemic index, insulin resistance, and beta-carotene.

Metabolic Bone Disease Cause

In addition, there are several other conditions that can cause metabolic bone disease. These conditions are collectively known as geopathic. The most common cause of the disease is vitamin D intoxication. Vitamin D is produced by the body in significant quantities during childhood and adolescence, usually following infection or trauma. When adults require vitamin D, they generally suffer from vitamin D intoxication due to nutritional insufficiency, chronic alcoholism, chemotherapy, or continuous use of certain drugs such as birth control pills. A rarer cause of the disease is autoimmune thyroid disease, in which the thyroid gland produces antibodies against itself.

Since the main means of bone formation in the human body is through normal remodeling processes, any abnormality in the process of remodeling can cause the breakdown of connective tissue. This process is called resorption. Studies in both animals and humans have confirmed that chronic malnutrition causes the breakdown of collagen, a fibrous protein, and myofibrils, with consequent loss of strength and structural integrity. Similarly, excessive calcium intake results in calcium resorption, leading to bone deterioration.

Metabolic bone diseases can be prevented by maintaining a healthy diet, sufficient water intake, regular exercise, and avoidance of harsh chemicals. Vitamin D supplements may also be used to prevent metabolic bone disease. However, calcium supplements are recommended to treat conditions of excessive calcium deficiency, kidney disease, malignant tumors, and patients undergoing dialysis. Estrogen supplementation and birth control pills are also prescribed in some cases. Long-term treatment of these conditions is not recommended.

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