Quincke’s Disease is one of the diseases that has been recently investigated. His diagnosis and subsequent treatment are what made this condition so infamous. The name “Quincke” itself derives from the German term “klin” which means “stroke”. In his book “Principles of Diagnosing and Treating Hypertension”, Quincke described symptoms of this condition in clinical terms and recommended early treatment for all hypertensive patients. It is estimated that over two million people in North America alone suffer from this disease.
Diagnosing Quincke Disease
The diagnosis of this condition typically involves a complete blood count, urine test, blood culture, urinalysis, and skin biopsy. Clinical manifestations consist of an enlarged nonary erythrocyte vascular mass, usually measured at the umbilical circumference, a palpable mass on the margin of the umbilical region, swollen lymph nodes, and a generally ill-health condition. A genetic form of nonhereditary Angiotensin-converting enzyme is typically responsible for a cellular defect; this has to be differentiated from primary, genetically related Angiotensin-converting enzyme (ACE) that is found in most people, which can also cause a hypervascular condition like quincke’s disease. In patients with acute dysfunctions of the kidney, chronic obstructive pulmonary disease, or severe acidosis, quincke’s disease symptoms can be mistaken for those conditions.
Treatments of Quincke’s Disease
Quincke’s Disease Treatment is based on the principle that biological therapies may slow and prevent the progression of this condition. This is achieved by improving the efficiency of the kidney in processing and distributing wastes. Treatment includes fluid infusion, antibiotic therapy, immunoadsorption therapy, corticosteroid therapy, and photodynamic therapy. Fluid infusion is intended to maintain adequate fluid volume in patients with isolated uvular angioedema. Antibiotics are usually prescribed for patients with mild to moderate quincke’s disease.
Photodynamic therapy is a type of treatment that utilizes chemical compounds to prevent the appearance of quincke’s disease. This method was developed specifically to treat isolated uvular angioedema in association with thermal injury. The treatment involves a series of photodynamic therapy sessions in which high-energy blue ultraviolet light is used to inhibit photochemical activation and increase photoreceptor sensitivity in patients with this condition. As photodynamic therapy is relatively rare and requires multiple sessions, it is often reserved as a last line of defense for treating quincke’s disease. Steroids, immunoadsorption therapy, and steroidal injections may be administered in conjunction with photodynamic therapy in patients with isolated uvular angioedema.
Quincke’s Disease is also known as hereditary angioedema and is an inherited form of chronic renal (HR) disease. This is a disorder in which the kidney does not function properly and excessive amounts of potassium and salt (renin) build up in the blood. In addition to quincke’s disease, inherited forms include Wilson’s disease, primary hyperparathyroidism, secondary hyperparathyroidism, congenital heart failure, and idiopathic hyperprolactinemia.
There is some debate as to whether quincke’s disease is an inherited condition. Treatment for this condition is normally focused on managing the underlying symptoms. Quincke’s Disease responds well to short-term blood thinners, diuretics, and antioxidants (AHA, selenium, lutein, alpha-lipoic acid). Herbal remedies are also used for this condition. This relatively rare condition may respond to treatments that include quercetin, resveratrol, flavonoids, vitamin E, and coenzyme Q10.